Apigenin and NAD In the context of aging and metabolism, apigenin is shown to inhibit the activity of CD38 CD38 is an enzyme that consumes NAD in ever increasing amounts as we get older NAD is a coenzyme found in all living cells and is essential for cellular function, DNA repair, and life Given that CD38 actively degrades both NAD and NMN, it may be a useful approach to use CD38 inhibitors such as apigenin to increase NAD levels rather than try to boost them with precursors In other words, it is better to treat the cause of NAD loss rather than trying to compensate for it
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